Simone Xavier, founder and chief creative officer of Sigma Beauty, explains. 'You should sanitize your brushes with a makeup brush spray after each use,' Dr. Expert Tips for Cleaning Your Makeup Brushes Plus, if you're trying not to touch your face as often, you should also make sure you're cleaning your makeup brushes on a regular basis. Giving your makeup brushes a proper cleaning is as necessary as washing your face before bed, yet we tend to forget about doing it regularly. But one area that often gets overlooked is our makeup stash and brushes. These days, it's safe to say that we’ve become hyperaware of germs and the importance of proper cleaning in our daily lives.